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KMID : 0387820160230010028
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Clinical Pediatric Hematology-Oncology
2016 Volume.23 No. 1 p.28 ~ p.33
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Prognostic Significance of IL-10 in Childhood Chronic Immune Thrombocytopenic Purpura
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Lee Gi-Min
Kim Ji-Yoon
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Abstract
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Background: The proposal of the present study was to assess the cytokine imbalances such as serum levels of IL-2, IL-10 and TGF-1 in childhood chronic ITP during the thrombocytopenic and spontaneous remission phases. The findings of this study are an-ticipated to offer new insights into the pathogenesis of childhood chronic ITP and the prognostic factors involved in spontaneous remission.
Methods: Ten children with chronic ITP, 6 thrombocytopenic and 4 recovered cases, were enrolled. Five healthy children and eight healthy adults were included in this study as controls. The serum levels of IL-2, IL-10 and TGF-1 were measured by ELISA technique.
Results: During this study, four patients achieved spontaneous remission. The serum lev-el of IL-10 was higher in the patients that recovered spontaneously compared to the patients with persistent chronic thrombocytopenia. The serum level of IL-2 was not able to be detected as the levels were too low for analysis. TGF-1 showed no significant differences among the groups in this study.
Conclusion: These data suggest that increased serum level of IL-10 could have prognostic significance in the natural course and long-term outcome of childhood chronic ITP.
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KEYWORD
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Child, Chronic ITP, Cytokine, IL-10, Natural course
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